Proapoptotic Proteins Escape Caspase-Mediated Conversion to Antiapoptotic Herpesvirus Bcl-2 Homologs

نویسندگان

  • William H. Burns
  • Marie Hardwick
  • David S. Bellows
  • B. Nelson Chau
  • Percy Lee
  • Yuri Lazebnik
  • DAVID S. BELLOWS
  • B. NELSON CHAU
  • PERCY LEE
  • YURI LAZEBNIK
  • WILLIAM H. BURNS
چکیده

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Antiapoptotic herpesvirus Bcl-2 homologs escape caspase-mediated conversion to proapoptotic proteins.

The antiapoptotic Bcl-2 and Bcl-x(L) proteins of mammals are converted into potent proapoptotic factors when they are cleaved by caspases, a family of apoptosis-inducing proteases (E. H.-Y. Cheng, D. G. Kirsch, R. J. Clem, R. Ravi, M. B. Kastan, A. Bedi, K. Ueno, and J. M. Hardwick, Science 278:1966-1968, 1997; R. J. Clem, E. H.-Y. Cheng, C. L. Karp, D. G. Kirsch, K. Ueno, A. Takahashi, M. B. K...

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تاریخ انتشار 2000